In this article, we report on a 40-year-old man with relapsing polycho
ndritis (RP) of the tracheobronchial tree without clinical manifestati
ons of other systems including nasal septum and earlobe cartilage invo
lvement. The illness was diagnosed histologically, and treatment with
procaine penicillin was successful. RP is an unusual systemic disorder
characterized by widespread inflammation and destruction of cartilage
tissues. The main cause is usually autoimmune. In RP various clinical
manifestations including nasal chondritis, arthritis, scleritis, dama
ge to tracheal and bronchial cartilage, and aortic, cardiac, and renal
involvement may occur. Isolated tracheobronchial involve ment is very
rare. The diagnosis must be based on a combination of clinical and pa
thologic features. If diagnosed early, appropriate treatment may preve
nt life-threatening airway obstruction.