SYNTHESIS AND BIOLOGICAL-ACTIVITY OF SOME NEW PYRIMIDINES

Pyrimidinthione 1 was reacted with benzylidenemalononitrile 2 to yield pyrimidothiazine 4. The synthesis of arylidenothiazolopyrimidines 7 w as achieved by the reaction of chloroacetic acid, aldehydes and pyrimi dinthione 1 in the presence of base. Aminothiazolopyrimidine 9 was obt ained from the reaction of compound 1 with chloroacetonitrile. Reactio n of ethyl bromoacetate with compound 1 afforded ethoxycarbonylmethylm ercaptopyrimidine 10. Compound 1 was reacted with NaOCl in the presenc e of NaOH/NH4OH to give sulphenamide 13 that undergoes cyclization by using benzoyl chloride to give 14.