SYNTHESIS OF SOME NEW (3H)-OXOQUINAZOLIN-3-YL]-5-ARYL-1,3,4-THIADIAZOLES AS POTENTIAL ANTINFLAMMATORY AGENTS

Twelve new 2-[2,6,8-trisubstituted-4 (3H)-oxoquinazolin-3-yl]-5-aryl-1 ,3,4-thiadiazoles (9-20) were synthesized by reacting different aromat ic carboxylic acids with corresponding 2,6,8-trisubstituted-3-thiosemi carbazido -4 (3H)-quinazolones (5-8). These thiosemicarbazido -4(3H)-q uinazolones, on the other hand, were obtained by the condensation of 3 -amino-2,6,8-trisubstitued -4(3H)-quinazolones (1-4) with carbon disul fide ammonia and hydrazine hydrate. All these intermediate compounds a nd the title compounds were characterized by their analytical and spec tral data. Many of the title compounds were found to be good antiinfla mmatory agents on evaluation.