THROMBOLYTIC AND ANTIPLATELET ACTION OF XANTHINOL NICOTINATE (SADAMIN), POSSIBLE MECHANISMS

Here we report on thrombolytic and hypotensive actions of Xanthinol ni cotinate (Sadamin) in rats and on its anti-platelet and fibrinolytic e ffects in patients with peripheral arterial obliterative disease (PAOD ). Special consideration was given to a proposal of new mechanisms of anti-platelet and thrombolytic actions of Sadamin, We conclude that th e mechanism of anti-platelet and thrombolytic activity of Sadamin part ly consists of a simultaneous release of endogenous prostacyclin and n itric oxide by the nicotinate component of Sadamin, whereas the theoph ylline component is responsible for enhancement of physiological actio ns of these endothelial mediators at the level of cyclic nucleotides w hich are their second messengers.