CARDIAC-FUNCTION AND OXYGEN BALANCE IN SEPTIC PATIENTS DURING CONTINUOUS HEMOFILTRATION

The aim of this work was to study hemodynamic, oximetric and metabolic parameters in septic patients during continuous hemofiltration, in or der to determine whether the changes in hemodynamic parameters can inf luence the oxygen utilization in peripheral tissues, 29 multiple organ failure patients with septic shock were studied during the first 48 h of continuous hemofiltration: 18 were submitted to CAVH and 11 patien ts were treated with CAVHD to correct ARF and fluid overload. Our data show that RVEF improves and REDVI reduces progressively during treatm ent, together with a significant reduction of the cardiac index after 48 h of CAVH(D). There were no significant variations in oxygen tissue parameters, while plasma lactate was reduced significantly, In conclu sion, our data confirm that continuous hemofiltration may be useful in septic patients to correct fluid overload and ARF, without affecting hemodynamic stability and oxygen balance. Moreover, in septic patients , this technique improves hemodynamics, reduces the filling pressure i n the right heart and reduces hyperdynamic response as CI and SVRI, wi thout any negative effects on O-2 balance.