EFFECT OF CROSS-LINKING BY FACTOR XIIIA ON THE MIGRATION OF VASCULAR SMOOTH-MUSCLE CELLS INTO FIBRIN GELS

Authors
NAITO M NOMURA H IGUCHI A THOMPSON WD SMITH EB
Citation
M. Naito et al., EFFECT OF CROSS-LINKING BY FACTOR XIIIA ON THE MIGRATION OF VASCULAR SMOOTH-MUSCLE CELLS INTO FIBRIN GELS, Thrombosis research, 90(3), 1998, pp. 111-116
Citations number
21
Categorie Soggetti
Hematology,"Peripheal Vascular Diseas
Journal title
Thrombosis research → ACNP
ISSN journal
00493848
Volume
90
Issue
3
Year of publication
1998
Pages
111 - 116
Database
ISI
SICI code
0049-3848(1998)90:3<111:EOCBFX>2.0.ZU;2-Q
Abstract
We evaluated the migration of vascular smooth muscle cells into crossl inked fibrin gels, using an in vitro assay system. Vascular smooth mus cle cells from bovine fetal aorta migrated into non-crosslinked and cr osslinked fibrin gels and showed a characteristic elongated spindle-sh aped appearance with long cytoplasmic processes. The cells displayed t wo-fold increase in migration into crosslinked fibrin gels compared to non-crosslinked gels, suggesting the importance of fibrin crosslinkin g by factor XIIIa on its three-dimensional structure for the migration of smooth muscle cells. (C) 1998 Elsevier Science Ltd.