DOES DEXTRAN-40 IMPROVE THE EARLY PATENCY OF AUTOGENOUS INFRAINGUINALBYPASS GRAFTS

Purpose: We determined whether the administration of dextran 40 would increase the early (30-day) patency of autogenous infrainguinal bypass grafts. Methods: During a 4-year period, 244 patients undergoing 273 autogenous infrainguinal bypass grafts were prospectively enrolled int o and completed this study. Patients were randomized into two groups; one of the groups received a 72-hour infusion of dextran 40 after surg ery, and the other did not. Comparisons were made between those patien ts who did and did not receive dextran 40 with respect to risks factor s, demographics, and early graft patency. Results: One hundred twenty- six procedures were accompanied by the use of dextran; 147 were not. T here was no significant difference between the two groups with respect to patient age, gender, perioperative risk factors, indication for su rgery, or location of bypass graft (popliteal vs tibial). Among those patients receiving dextran, there were eight early occlusions (6.4%) a nd four deaths (3.2%); 89.7% of the patients were alive with patent gr afts 30 days after surgery. In the group not receiving dextran, there were 10 early occlusions (6.8%) and 3 deaths (2%); 90.5% of the patien ts were alive with patent grafts 30 days after surgery. There was no s ignificant difference between the two groups with respect to rate of e arly occlusion (p = 1.00), death (p = 0.71), or 30-day patency (p = 0. 84). Conclusions: The administration of dextran 40 does not increase t he early patency of autogenous infrainguinal bypass grafts. Its routin e use during these procedures cannot be recommended.