CEREBRAL VENOUS THROMBOSIS AND PROCOAGULANT FACTORS - A CASE-STUDY

Cerebral venous thrombosis is a polymorphic clinical entity for which diagnosis has become more frequent with the advent of neuroradiology. The superior sagittal and transverse sinuses are frequently involved, whereas cavernous sinus thrombosis is much less frequent. Inherited re sistance to the anticoagulant action of activated protein C (APC resis tance), antithrombin deficiency, protein C and S deficiencies, and hyp erhomocysteinemia seem to represent major causes of thrombophilia when unusual thromboembolic events (ie, before the age of 45 years) are ob served. The authors present the combined occurrence of protein C and p rotein S deficiencies in a 32-year-old woman, manifested by extensive cerebralvenous thrombosis.