ANTICONVULSANT EFFECTS OF NIMODIPINE AND 2 NOVEL DIHYDROPYRIDINES (PCA-50922 AND PCA-50941) AGAINST SEIZURES ELICITED BY PENTYLENETETRAZOLEAND ELECTROCONVULSIVE SHOCK IN MICE

Authors
ZAPATER P JAVALOY J ROMAN JF VIDAL MT HORGA JF
Citation
P. Zapater et al., ANTICONVULSANT EFFECTS OF NIMODIPINE AND 2 NOVEL DIHYDROPYRIDINES (PCA-50922 AND PCA-50941) AGAINST SEIZURES ELICITED BY PENTYLENETETRAZOLEAND ELECTROCONVULSIVE SHOCK IN MICE, Brain research, 796(1-2), 1998, pp. 311-314
Citations number
12
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
796
Issue
1-2
Year of publication
1998
Pages
311 - 314
Database
ISI
SICI code
0006-8993(1998)796:1-2<311:AEONA2>2.0.ZU;2-C
Abstract
In animal models of epilepsy, calcium entry blockers have shown antico nvulsant properties. We studied the antiepileptic effects of nimodipin e and two novel dihydropyridines, a calcium antagonist (PCA 50922) and a calcium agonist (PCA 50941), on pentylenetetrazole seizure and maxi mal electroshock seizure (MES) in mice. Anticonvulsant profile of nimo dipine and PCA 50922 was similar to that of clonazepam, but markedly d ifferent from that of phenytoin. None of the doses of the PCA 50941 sh owed anticonvulsant effect. (C) 1998 Elsevier Science B.V. All rights reserved.