MICROINJECTION OF MORPHINE INTO THE ROSTRAL VENTROMEDIAL MEDULLA PRODUCES GREATER ANTINOCICEPTION IN MALE COMPARED TO FEMALE RATS

Authors
BOYER JS MORGAN MM CRAFT RM
Citation
Js. Boyer et al., MICROINJECTION OF MORPHINE INTO THE ROSTRAL VENTROMEDIAL MEDULLA PRODUCES GREATER ANTINOCICEPTION IN MALE COMPARED TO FEMALE RATS, Brain research, 796(1-2), 1998, pp. 315-318
Citations number
31
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
796
Issue
1-2
Year of publication
1998
Pages
315 - 318
Database
ISI
SICI code
0006-8993(1998)796:1-2<315:MOMITR>2.0.ZU;2-0
Abstract
The antinociceptive and locomotor effects of microinjecting morphine i nto the rostral ventromedial medulla (RVM) of male and female rats was assessed. Male rats showed greater antinociception than female rats a t all doses and times following morphine administration. Male, but not female rats, also showed a dose dependent decrease in locomotion. The se data demonstrate that sex differences in antinociception are mediat ed at least in part by the RVM. (C) 1998 Elsevier Science B.V. All rig hts reserved.