THERMODYNAMIC AND KINETIC-PARAMETERS FROM ISOTHERMAL HEAT-CONDUCTION MICROCALORIMETRY

Recent developments have led to a general procedure that allows the an alysis of microcalorimetric data to determine both kinetic and thermod ynamic parameters. This makes microcalorimetry a technique with a pote ntial for the accurate prediction of long-term stability, and excipien t compatibility, of pharmaceutical compounds. The data presented here show the uses and limitations of this general method when applied to s imple solution phase reactions, that are fast to medium term in durati on, and suggest how the method may be extended to more complex heterog eneous systems that reflect cases which may be encountered industriall y.