A VIRAL MECHANISM FOR INHIBITION OF THE CELLULAR PHOSPHATASE CALCINEURIN

Authors
MISKIN JE ABRAMS CC GOATLEY LC DIXON LK
Citation
Je. Miskin et al., A VIRAL MECHANISM FOR INHIBITION OF THE CELLULAR PHOSPHATASE CALCINEURIN, Science, 281(5376), 1998, pp. 562-565
Citations number
17
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Science → ACNP
ISSN journal
00368075
Volume
281
Issue
5376
Year of publication
1998
Pages
562 - 565
Database
ISI
SICI code
0036-8075(1998)281:5376<562:AVMFIO>2.0.ZU;2-S
Abstract
The transcription factor NFAT (nuclear factor of activated T cells) co ntrols the expression of many immunomodulatory proteins. African swine Fever virus inhibits proinflammatory cytokine expression in infected macrophages, and a viral protein A238L was found to display the activi ty of the immunosuppressive drug cyclosporin A by inhibiting NFAT-regu lated gene transcription in vivo. This it does by binding the catalyti c subunit of calcineurin and inhibiting calcineurin phosphatase activi ty.