This study was undertaken to determine the specificity of prenatal dia
gnosis of posterior urethral valves. Twenty-two fetuses were diagnosed
in utero with posterior urethral valves due to the presence of persis
tent megacystis and hydronephrosis. Ten cases had oligohydramnios and
12 had normal or increased fluid. Confirmation of diagnosis was not av
ailable in 3 fetuses. Only 8 of 19 fetuses had postnatal confirmation
of posterior urethral valves. Other anomalies included urethral atresi
a, ureteral duplication, megacystis/megaureter, reflux and multicystic
dysplastic kidney. We conclude that in utero evidence of megacystis a
nd hydronephrosis with or without oligohydramnios is not diagnostic of
posterior urethral valves.