POTENTIAL TUMOR DOUBLING TIME - DETERMINATION OF T-POT FOR VARIOUS CANINE AND FELINE TUMORS

Spontaneous tumours in dogs and cats are an excellent model for clinic al human research, such as in developing: proton conformation radiothe rapy for humans. The kinetics of tumour cells can be used effectively to predict prognosis and response to therapy in patients with tumours. Knowledge of the kinetic parameters in these rumours is therefore imp ortant. In the present study the kinetic parameters evaluated included the labelling index (LI), relative movement (RM), mitotic index (MI), and potential doubling time (T-pot). These parameters were determined using in vivo labelling with bromodeoxyuridine, flow cytometry and hi stological preparation. Samples were obtained and evaluated from 72 do gs and 20 cats, presenting as patients in our clinic. Within the group s of epithelial and mesenchymal rumours from dogs and cats, the kineti c parameters LI, RM and MI were compared with T-pot. Significant corre lations were observed for the comparison T-pot and LI. No correlation was found between T-pot and RM.