Purpose: Lipoma arborescens (LA) is a rare, poorly understood intraart
icular lesion, with few cases reported in the imaging literature. Our
purpose was to describe on MR the different morphologic appearances of
LA of the knee and to investigate the incidence of associated anomali
es. Method: The medical records and MR findings of 12 patients with pr
oven LA in 13 knee joints were retrospectively reviewed with particula
r emphasis on the shape of the lesion, location, signal intensity, and
past clinical history. Results: We found three common morphological p
atterns of presentation: multiple villous lipomatous synovial prolifer
ations (n = 6), isolated frond-like fat subsynovial mass (n = 2), and
mixed pattern (n = 5). Multiple villous lipomatous synovial proliferat
ions and mixed pattern were usually associated with a history of traum
a and/or chronic inflammatory diseases. However, the least frequent is
olated frond-like fat subsynovial mass appears to originate without an
tecedent. The durations of symptoms were 1-7 months (multiple villous
lipomatous synovial proliferations), 1-20 years (mixed pattern), and 6
-7 years (isolated frond-like subsynovial fat mass). Conclusion: Our s
tudy suggests that LA can present with a variety of morphological appe
arances on MR that may depend on the previous clinical history and dur
ation of the disease.