ACCURACY OF THE CLINICAL DIAGNOSES OF LEWY BODY DISEASE, PARKINSON-DISEASE, AND DEMENTIA WITH LEWY BODIES

Citation
I. Litvan et al., ACCURACY OF THE CLINICAL DIAGNOSES OF LEWY BODY DISEASE, PARKINSON-DISEASE, AND DEMENTIA WITH LEWY BODIES, Archives of neurology, 55(7), 1998, pp. 969-978
Citations number
91
Categorie Soggetti
Clinical Neurology
Journal title
ISSN journal
00039942
Volume
55
Issue
7
Year of publication
1998
Pages
969 - 978
Database
ISI
SICI code
0003-9942(1998)55:7<969:AOTCDO>2.0.ZU;2-K
Abstract
Background: Whether Parkinson disease (PD) and dementia with Lewy bodi es (DLB) represent 2 distinct nosologic entities or are diverse phenot ypes of Lewy body disease is subject to debate. Objectives: To determi ne the accuracy of the diagnoses of lewy body disease, PD, and DLB by validating the clinical diagnoses of 6 neurologists with the neuropath ologic findings and to identify early predictors of the diagnoses. Met hods: Six raters who were unaware of the neuropathologic diagnoses ana lyzed 105 clinical vignettes corresponding to 29 cases of Lewy body di sease (post hoc analysis of 15 patients with PD and 14 with DLB) and 7 6 patients without PD or DLB whose cases were confirmed through autops y findings. Main Outcome Measures: Sensitivity and positive predictive value (PPV) were chosen as validity measures and the kappa statistic as a reliability measure, Results: Interrater reliability for the diag noses of Lewy body disease and PD was moderate for the first visit and substantial for the last, whereas agreement for diagnosis of DLB was fair for the first visit and slight for the last. Median sensitivity f or diagnosis of Lewy body disease was 56.9% for the first visit and 67 .2% for the last; median PPV was 60.0% and 77.4%, respectively. Median sensitivity for the diagnosis of PD was 73.3% for the first visit and 80.0% for the last; median PPV was 45.9% and 64.1%, respectively. Med ian sensitivity for the diagnosis of DLB was 17.8% for the first visit and 28.6% for the last; median PPV was 75.0% for the first visit and 55.8% for the last. The raters' results were similar to those of the p rimary neurologists. Several features differentiated PD from DLB, pred icted each disorder, and could be used as clinical pointers. Conclusio ns: The low PPV with relatively high sensitivity for the diagnosis of PD suggests overdiagnosis. Conversely, the extremely low sensitivity f or the diagnosis of DLB suggests underdiagnosis. Although the case mix included in the study may not reflect the frequency of these disorder s in practice, limiting the clinical applicability of the validity mea sures, the raters' results were similar to those of the primary neurol ogists who were not exposed to such limitations. Overall, our study co nfirms features suggested to predict these disorders, except for the e arly presence of postural imbalance, which is not indicative of either disorder.