I. Litvan et al., ACCURACY OF THE CLINICAL DIAGNOSES OF LEWY BODY DISEASE, PARKINSON-DISEASE, AND DEMENTIA WITH LEWY BODIES, Archives of neurology, 55(7), 1998, pp. 969-978
Background: Whether Parkinson disease (PD) and dementia with Lewy bodi
es (DLB) represent 2 distinct nosologic entities or are diverse phenot
ypes of Lewy body disease is subject to debate. Objectives: To determi
ne the accuracy of the diagnoses of lewy body disease, PD, and DLB by
validating the clinical diagnoses of 6 neurologists with the neuropath
ologic findings and to identify early predictors of the diagnoses. Met
hods: Six raters who were unaware of the neuropathologic diagnoses ana
lyzed 105 clinical vignettes corresponding to 29 cases of Lewy body di
sease (post hoc analysis of 15 patients with PD and 14 with DLB) and 7
6 patients without PD or DLB whose cases were confirmed through autops
y findings. Main Outcome Measures: Sensitivity and positive predictive
value (PPV) were chosen as validity measures and the kappa statistic
as a reliability measure, Results: Interrater reliability for the diag
noses of Lewy body disease and PD was moderate for the first visit and
substantial for the last, whereas agreement for diagnosis of DLB was
fair for the first visit and slight for the last. Median sensitivity f
or diagnosis of Lewy body disease was 56.9% for the first visit and 67
.2% for the last; median PPV was 60.0% and 77.4%, respectively. Median
sensitivity for the diagnosis of PD was 73.3% for the first visit and
80.0% for the last; median PPV was 45.9% and 64.1%, respectively. Med
ian sensitivity for the diagnosis of DLB was 17.8% for the first visit
and 28.6% for the last; median PPV was 75.0% for the first visit and
55.8% for the last. The raters' results were similar to those of the p
rimary neurologists. Several features differentiated PD from DLB, pred
icted each disorder, and could be used as clinical pointers. Conclusio
ns: The low PPV with relatively high sensitivity for the diagnosis of
PD suggests overdiagnosis. Conversely, the extremely low sensitivity f
or the diagnosis of DLB suggests underdiagnosis. Although the case mix
included in the study may not reflect the frequency of these disorder
s in practice, limiting the clinical applicability of the validity mea
sures, the raters' results were similar to those of the primary neurol
ogists who were not exposed to such limitations. Overall, our study co
nfirms features suggested to predict these disorders, except for the e
arly presence of postural imbalance, which is not indicative of either
disorder.