A patient with pericardial tamponade secondary to malignant pericardia
l effusion underwent pericardiocentesis followed by intrapericardial i
nstillation of recombinant interferon alfa-2b (INTRON A; Schering-Plou
gh; Kenilworth NJ). The patient subsequently received a full course of
chemotherapy and radiation therapy for her primary malignant tumor an
d experienced no recurrence of the pericardial effusion.