THE PATHOPHYSIOLOGICAL ROLE OF ESTROGEN-RECEPTOR VARIANTS IN HUMAN BREAST-CANCER

Authors
MURPHY LC DOTZLAW H LEYGUE E COUTTS A WATSON P
Citation
Lc. Murphy et al., THE PATHOPHYSIOLOGICAL ROLE OF ESTROGEN-RECEPTOR VARIANTS IN HUMAN BREAST-CANCER, Journal of steroid biochemistry and molecular biology, 65(1-6), 1998, pp. 175-180
Citations number
39
Categorie Soggetti
Biology,"Endocrynology & Metabolism
Journal title
Journal of steroid biochemistry and molecular biology → ACNP
ISSN journal
09600760
Volume
65
Issue
1-6
Year of publication
1998
Pages
175 - 180
Database
ISI
SICI code
0960-0760(1998)65:1-6<175:TPROEV>2.0.ZU;2-Q
Abstract
The accumulated evidence supports the expression of estrogen receptor variants at both the mRNA and protein levels. The relative level of ex pression of some estrogen receptor variant mRNAs and possibly progeste rone receptor variant mRNAs is altered during breast tumorigenesis and breast cancer progression. The altered expression of estrogen recepto r variants may effect estrogen signal transduction as well as the inte rpretation of assays where the estimation of estrogen receptor levels is used as a guide to treatment strategies and prognosis. (C) 1998 Els evier Science Ltd. All rights reserved.