H-1 AND C-13 NMR DETERMINATION OF THE ENANTIOMERIC PURITY OF SUBSTITUTED 4-AMINO-3-(THIEN-2-YL)-BUTYRIC ACIDS AND 4-AMINO-3-(BENZO[B]FURAN-2-YL)-BUTYRIC ACIDS, LIGANDS OF THE GABA(B) RECEPTOR

Authors
ALAKOUMEBRIK S ANSAR M MOUHOUB R VACCHER C VACCHER MP FLOUQUET N
Citation
S. Alakoumebrik et al., H-1 AND C-13 NMR DETERMINATION OF THE ENANTIOMERIC PURITY OF SUBSTITUTED 4-AMINO-3-(THIEN-2-YL)-BUTYRIC ACIDS AND 4-AMINO-3-(BENZO[B]FURAN-2-YL)-BUTYRIC ACIDS, LIGANDS OF THE GABA(B) RECEPTOR, Spectroscopy letters, 31(5), 1998, pp. 925-944
Citations number
26
Categorie Soggetti
Spectroscopy
Journal title
Spectroscopy letters → ACNP
ISSN journal
00387010
Volume
31
Issue
5
Year of publication
1998
Pages
925 - 944
Database
ISI
SICI code
0038-7010(1998)31:5<925:HACNDO>2.0.ZU;2-1
Abstract
The enantiomeric composition and absolute configuration of 4-Amino-3-( benzo[b]furan-2-yl)- Butanoic Acids and of 4-Amino-3-(thien-2-yl)- But anoic Acids 1 may be accurately determined by H-1 and C-13 nuclear mag netic resonance analysis of the corresponding derivatives 3 prepared b y reaction with chiral reagents. Correlation with HPLC is signaled.