ULTRASTRUCTURAL, CELL-CULTURE AND KARYOTYPE STUDY OF BONE-MARROW IN APATIENT WITH CONGENITAL DYSERYTHROPOIETIC ANEMIA (CDA)-TYPE-III PRESENTING WITH RECURRENT STILL-BIRTHS

A 28 year old female patient presented with refractory anaemia since c hildhood and recurrent still-births at 28-30 weeks of gestation. One s till-born child was hydropic at birth. Bone marrow showed characterist ic morphological changes of congenital dyserythropoietic anaemia (CDA) Type III. Electron microscopy showed disruption of the nuclear membran e, spongy appearance of nuclei, stacks of microtubules in intermediate normoblasts and myelin figures in erythroid cells. In vitro culture a nd karyotype data from the bone marrow of the patient is presented. Re current stillbirths in association with congenital dyserythropoietic a naemia has rarely been reported in the literature.