FUTURE CONSIDERATIONS IN HTS - THE ACUTE EFFECT OF CHRONIC DILEMMAS

Today, in the area of Biomolecular Screening, it would seem that 'some thing better' in terms of instrumentation or assay technology, is emer ging almost every week. From the standpoint of planning, this presents significant challenges to decide whether to integrate the 'latest and greatest' advance, whether to wait just a few months for the next adv ance, which may make the current advance obsolete, or perhaps to maint ain the status quo. This decision would be considerably simpler if the re was a clear, optimal strategy for identifying and selecting lead co mpound This article attempts to look at this issue from the perspectiv e of discussing the pros and cons to several approaches to lead discov ery.