STREPTOZOTOCIN-INDUCED DIABETIC CYNOMOLGUS MONKEY IS A MODEL OF HYPERTRIGLYCERIDEMIA WITH LOW HIGH-DENSITY-LIPOPROTEIN CHOLESTEROL

Hypertriglyceridemia with low high-density lipoprotein (HDL) cholester ol is a risk factor of cardiovascular disease. We attempted to create an animal model of hypertriglyceridemia with low HDL cholesterol by in travenously injecting 30 mg/kg body weight streptozotocin (STZ) to cyn omolgus monkeys. This induced hypoinsulinemia and resulted in a decrea se in postheparin plasma lipoprotein lipase (LPL) activity and LPL enz yme mass, reduction of plasma HDL cholesterol and elevation of triglyc erides, Low HDL cholesterol subsequently caused a reduction of HDL,, c holesterol, while hypertriglyceridemia caused an elevation of very low -density lipoprotein (VLDL) triglyceridemia, Apolipoprotein CII, a co- factor of LPL, was not affected by STZ administration. These results s how that hypertriglyceridemia with low HDL cholesterol results from a reduction of LPL activity without affecting apolipoprotein CII after S TZ administration. The STZ-induced diabetic cynomolgus monkey is a mod el of hypertriglyceridemia with low HDL cholesterol, and may be potent ially beneficial for studying atherosclerosis caused by hypertriglycer idemia with low HDL cholesterol.