MAdCAM-1 specifically binds the lymphocyte integrin alpha(4)beta(7) an
d participates in the homing of leukocytes to intestinal mucosal sites
. The LDT sequence located on the CD loop of MAdCAM-1 is an important
binding site for MAdCAM-1/alpha(4)beta(7) interactions. N-Terminus acy
lation of the LDT motif and modification of the C-terminus carboxamide
with amines led to low micromolar MAdCAM-1 inhibitors. (C) 1998 Elsev
ier Science Ltd. All rights reserved.