SYNTHESIS OF A HIGH-MANNOSE-TYPE GLYCOPEPTIDE ANALOG CONTAINING A GLUCOSE-ASPARAGINE LINKAGE

Authors
DERAS IL TAKEGAWA K KONDO A KATO I LEE YC
Citation
Il. Deras et al., SYNTHESIS OF A HIGH-MANNOSE-TYPE GLYCOPEPTIDE ANALOG CONTAINING A GLUCOSE-ASPARAGINE LINKAGE, Bioorganic & medicinal chemistry letters, 8(13), 1998, pp. 1763-1766
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
13
Year of publication
1998
Pages
1763 - 1766
Database
ISI
SICI code
0960-894X(1998)8:13<1763:SOAHGA>2.0.ZU;2-4
Abstract
The title compound was prepared by enzymatic transfer of oligosacchari de to a synthetic pentapeptide containing the Glc-Asn linkage. The com pound was not hydrolyzed by glycoamidases from plant and bacterial sou rces, but it inhibited both enzymes in the micromolar range. Its activ ity is compared to other potential inhibitors. (C) 1998 Elsevier Scien ce Ltd. All rights reserved.