ABSOLUTE STEREOSTRUCTURES OF CARABRANE-TYPE SESQUITERPENES, CURCUMENONE, 4S-DIHYDROCURCUMENONE, AND CURCARABRANOL-A AND CURCARABRANOL-B - VASORELAXANT ACTIVITY OF ZEDOARY SESQUITERPENES

Authors
YOSHIKAWA M MURAKAMI T MORIKAWA T MATSUDA H
Citation
M. Yoshikawa et al., ABSOLUTE STEREOSTRUCTURES OF CARABRANE-TYPE SESQUITERPENES, CURCUMENONE, 4S-DIHYDROCURCUMENONE, AND CURCARABRANOL-A AND CURCARABRANOL-B - VASORELAXANT ACTIVITY OF ZEDOARY SESQUITERPENES, Chemical and Pharmaceutical Bulletin, 46(7), 1998, pp. 1186-1188
Citations number
7
Categorie Soggetti
Chemistry Medicinal",Chemistry,"Pharmacology & Pharmacy
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
46
Issue
7
Year of publication
1998
Pages
1186 - 1188
Database
ISI
SICI code
0009-2363(1998)46:7<1186:ASOCSC>2.0.ZU;2-J
Abstract
New carabrane-type sesquiterpenes, curcarabranols A and B, were isolat ed from zedoary together with the two known carabrane-type sesquiterpe nes curcumenone and 4S-dihydrocurcumenone. The absolute stereostructur es of these carabrane-type sesquiterpenes were determined on the basis of physicochemical and chemical evidence, Zedoary sesquiterpenes incl uding 4S-dihydrocurcumenone and curcarabranols A and B were found to i nhibit the contraction induced by a high concentration of K+ in isolat ed rat aortic strips.