AN EFFICIENT AND HIGHLY PRACTICAL SYNTHESIS OF TETRAHYDROFUROFURANE LIGNANS

A new route to tetrahydrofurofurane lignans 8 is present, which starts with substituted benzoate following a 7 step syntheses, and is distin ctly shorter, more economic and efficient than any of the previous app roaches to the target reported in the literature. The key step to esta blish the first furane ring 2 benefits the remarkable ease of the Diel s Alder reaction of 2,4-diaryloxazole 1 with 2-butyne-1,4-diol diaceta te.