ELECTROCHEMICAL DETERMINATION OF MINOCYCLINE IN PHARMACEUTICAL PREPARATIONS

The possibility of electrochemical determination of minocycline on mer cury and solid electrodes by various voltammetric and polarographic te chniques ha: been undertaken. The influence of some chemical (ionic st rength and pH) and instrumental parameters on the main reduction signa l of minocycline was investigated.The alternating current polarographi c (ACP) technique was applied to the minocycline determination either in pure form or in a commercial pharmaceutical preparation. The common excipients did not interfere. The antibiotic could be detected in the concentration range 1 10(-6) - 5 10(-6) mol L-1. The detection limit for the quantitative determination by ACP was 1 10(-6) mol L-1 minocyc line in aqueous medium of 0.1 M NaCl. The mean recovery was 99.2% with a relative standard deviation (RSD) of 2.93% (n = 8).