TARGETED THERAPY WITH A NOVEL ENEDIYENE ANTIBIOTIC CALICHEAMICIN THETA(I)(1) EFFECTIVELY SUPPRESSES GROWTH AND DISSEMINATION OF LIVER METASTASES IN A SYNGENEIC MODEL OF MURINE NEUROBLASTOMA

The suppression of metastases in malignant diseases is one of the majo r goals in targeted chemotherapy, This was achieved with an antibody d rug conjugate between a novel, rationally designed enediyene antibioti c calicheamicin theta(1)(1), of exceptionally high cytotoxic potency a nd an antiganglioside GD(2) monoclonal antibody 14G2a. Effective suppr ession of hepatic metastases was demonstrated in a novel syngeneic mod el of murine neuroblastoma that simulates the situation in patients in terms of antigen heterogeneity and presence of the target antigen on normal tissues. Here, we describe the first successful use of calichea micin theta(1)(1) for targeted chemotherapy in a clinically relevant s yngeneic metastasis model.