CLONING AND ANALYSIS OF A TRANSCRIPT DERIVED FROM 2 CONTIGUOUS GENES OF THE CATHELICIDIN FAMILY

Bac4 is a bovine cathelicidin gene contiguous to another member of thi s family named Bac7. Although mutations in the sequence suggested that Bac4 gene might be non-functional, primers based on Bac4 specific seq uences allowed amplification of a 900 bp cDNA, The transcript comprise s the sequences of exons 1, 2 and 3 of Bac7, and of exons 2, 3 and 4 o f Bac4 gene and may result from a weak termination control of the tran scription of the upstream Bac7 gene. (C) 1998 Elsevier Science B.V. Al l rights reserved.