SYNTHESIS OF TAXOIDS 3 - A NOVEL AND EFFICIENT METHOD FOR PREPARATIONOF TAXOIDS BY EMPLOYING CIS-GLYCIDIC ACID

Authors
YAMAGUCHI T HARADA N OZAKI K HASHIYAMA T
Citation
T. Yamaguchi et al., SYNTHESIS OF TAXOIDS 3 - A NOVEL AND EFFICIENT METHOD FOR PREPARATIONOF TAXOIDS BY EMPLOYING CIS-GLYCIDIC ACID, Tetrahedron letters, 39(31), 1998, pp. 5575-5578
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
31
Year of publication
1998
Pages
5575 - 5578
Database
ISI
SICI code
0040-4039(1998)39:31<5575:SOT3-A>2.0.ZU;2-R
Abstract
A novel route for the synthesis of docetaxel (2) using esterification of (2R,3R)glycidic acid with 7, 2,2,2-trichloroethoxycarbonyl)-10-deac etylbaccatin III is described. Subsequent stereo- and regio-selective conversion afforded 2 and related novel compounds. (C) 1998 Elsevier S cience Ltd. All rights reserved.