ACUTE EFFECTS OF SYSTEMIC BLOOD-FLOW ARREST ON FREE RADICAL-MEDIATED OXIDATION AND NO-SYNTHASE ACTIVITY IN CEREBRAL STRUCTURES OF RATS WITHDIFFERENT TYPES OF BEHAVIOR IN EMOTIONAL RESONANCE TEST

Free radical-mediated processes and NO-synthase activity were studied in cerebral structures and blood serum of male Wistar rats with differ ent types of behavior in emotional resonance test one hour after globa l ischemia induced by cardiac arrest. Oxidative stress accompanied by loss in NO-synthase activity was revealed in cerebral cortex after the ischemia. The oxidative stress was also evident in cerebellum and to a lesser extent in hippocampus. The majority of behavior-related bioch emical differences were induced by cardiac arrest. These differences c ould be global or related to specific brain structures. Sometimes they became apparent in cerebral lateralization of biochemical indices.