THE EFFECT OF ENVIRONMENT ON THE CHANGES IN CALMODULIN IN RAT-BRAIN PRODUCED BY REPEATED AMPHETAMINE TREATMENT

Rats were given repeated infusions of i.v. amphetamine in association with placement in a novel test environment, a protocol that produces b ehavioral sensitization, or in the home cage, a protocol that fails to induce sensitization. In several brain areas amphetamine altered calm odulin content, but only in the group treated in a novel environment, suggesting that amphetamine-induced alterations in calmodulin may occu r only when drug treatments induce behavioral sensitization. (C) 1998 Elsevier Science B.V. All rights reserved.