RING-OPENING CROSS-METATHESIS ON SOLID SUPPORT - A COMBINATORIAL LIBRARY SYNTHESIS OF HIGHLY FUNCTIONALIZED CYCLOPENTANES

Authors
CAO JG CUNY GD HAUSKE JR
Citation
Jg. Cao et al., RING-OPENING CROSS-METATHESIS ON SOLID SUPPORT - A COMBINATORIAL LIBRARY SYNTHESIS OF HIGHLY FUNCTIONALIZED CYCLOPENTANES, Molecular diversity, 3(3), 1998, pp. 173-179
Citations number
28
Categorie Soggetti
Chemistry Applied","Chemistry Medicinal
Journal title
Molecular diversity → ACNP
ISSN journal
13811991
Volume
3
Issue
3
Year of publication
1998
Pages
173 - 179
Database
ISI
SICI code
1381-1991(1998)3:3<173:RCOSS->2.0.ZU;2-I
Abstract
Ruthenium catalyzed ring opening cross-metathesis of resin-bound bicyc lic alkenes with terminal aryl olefins was utilized for the constructi on of a combinatorial library containing highly functionalized cyclope ntane derivatives. The technology described herein represents a conver gent method for the diastereospecific synthesis of unique cyclopentane molecular scaffolds useful for exploratory medicinal chemistry.