FACTOR-ANALYSIS IN NORMAL-PHASE LIQUID-CHROMATOGRAPHY OF N-BENZYLIDENEANILINES

The retentions of 72 substituted N-benzylideneanilines (NBA) in normal phase liquid chromatography were determined using seven eluents prepa red with heptan, tetrahydrofuran, octanol-1, and ethyl acetate. princi pal component analysis (PCA) and correspondence factor analysis (CFA) were applied to describe the behavior of the compounds. With PCA, only one factor is necessary to model the retention CFA offers an analysis of second-order effects and shows how the retention of the relevant c ompounds is related to the electronic effects. A multilinear regressio n with the Hammett's constants of substituents is established. The inf luence of the substituent position on retention is discussed.