LIPASE-CATALYZED SYNTHESIS OF CAPSAICIN ANALOGS BY AMIDATION OF VANILLYLAMINE WITH FATTY-ACID DERIVATIVES

Various lipases catalyzed the synthesis of capsaicin analogs by amidat ion of vanillylamine with fatty acid derivatives in a two-phase system . When methyl myristate was employed as an acyl donor, moderate yields , 40-59%, of capsaicin analog (3) were obtained using Novozym 435, Lip ase AK or Lipase PS. Several capsaicin analogs having 4-18 carboxyl ca rbons were also synthesized from the corresponding fatty acid or its m ethyl or ethyl ester in 2-44% yields.