PREPARATION AND CHIRAL RECOGNITION OF (S)-BINAPHTHOL DERIVATIVE-BONDED PHASE FOR HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

(S)-Binaphthol derivative-bonded phases were prepared for direct chira l separation by high-performance liquid chromatography. The bonded pha ses were prepared by methylation of the hydroxyl groups or introductio n of aryl groups at 3,3'-positions in the binaphthol moiety. Methylati on varied retention and enantioselectivity for amines, which clarified that the hydroxyl groups are essential for chiral recognition of amin es, Substitution of phenyl or naphthyl groups at 3,3'-positions of the binaphthol moiety increased both hydrophobicity and steric hindrance, which also vary retention and enantioselectivity of analytes. (C) 199 8 Elsevier Science B.V. All rights reserved.