STATISTICAL-METHODS FOR DNA-SEQUENCE SEGMENTATION

This article examines methods, issues and controversies that have aris en over the last decade in the effort to organize sequences of DNA bas e information into homogeneous segments. An array of different models and techniques have been considered and applied. We demonstrate that m ost approaches can be embedded into a suitable version of the multiple change-point problem, and we review the various methods in this light . We also propose and discuss a promising local segmentation method, n amely, the application of split local polynomial fitting. The genome o f bacteriophage lambda serves as an example sequence throughout the pa per.