THE EFFECT OF PSEUDORABIES VIRUS GROWTH-FACTOR (PRGF) ON EMBRYONIC AND LARVAL DEVELOPMENT OF ZEBRAFISH (DANIO-RERIO) AND JUVENILES OF GUPPY(POECILIA-RETICULATA)
Ja. Kovriznych et al., THE EFFECT OF PSEUDORABIES VIRUS GROWTH-FACTOR (PRGF) ON EMBRYONIC AND LARVAL DEVELOPMENT OF ZEBRAFISH (DANIO-RERIO) AND JUVENILES OF GUPPY(POECILIA-RETICULATA), BIOLOGIA, 53(3), 1998, pp. 331-341
The effect of pseudorabies virus growth factor (PRGF) on two fish spec
ies in two different developmental stages was investigated, namely, on
undifferentiated cells represented by fertilised zebrafish eggs, and
on already formed organisms represented by newly hatched guppy. PRGF d
issolved in water at concentrations 1x10(3) to 1x10(13) units/ml was t
eratogenic and at concentrations 1x10(7) to 1x10(13) units/ml was toxi
c. The importance and the extent of the effect was dependent on the ty
pe of affected cells, the concentration of PRGF and the stage when a c
ell was affected in the developing fish embryo. The exposure of Danio
rerio eggs to PRGF at high concentrations (1x10(7) to 1x10(13)) slowed
down significantly the development of juveniles and retarded the grow
th of their weight and length. On the other hand, PRGF at low concentr
ations (1x10(5) to 1x10(3)) significantly stimulated the growth of the
ir weight and length.