DETERMINATION OF LOSARTAN AND ITS DEGRADATES IN COZAAR(R) TABLETS BY REVERSED-PHASE HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHY

Authors
MCCARTHY KE WANG QX TSAI EW GILBERT RE IP DP BROOKS MA
Citation
Ke. Mccarthy et al., DETERMINATION OF LOSARTAN AND ITS DEGRADATES IN COZAAR(R) TABLETS BY REVERSED-PHASE HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHY, Journal of pharmaceutical and biomedical analysis, 17(4-5), 1998, pp. 671-677
Citations number
20
Categorie Soggetti
Pharmacology & Pharmacy","Chemistry Analytical
Journal title
Journal of pharmaceutical and biomedical analysis → ACNP
ISSN journal
07317085
Volume
17
Issue
4-5
Year of publication
1998
Pages
671 - 677
Database
ISI
SICI code
0731-7085(1998)17:4-5<671:DOLAID>2.0.ZU;2-N
Abstract
Losartan potassium is an angiotensin II receptor blocker. It has been formulated and marketed as a tablet dosage form (COZAAR(R). A reversed -phase high-performance thin-layer chromatography method has been deve loped for the determination of losartan and its low level dimeric degr adates (E and Fl. The method has been validated and shown to be sensit ive, efficient. and reliable, and can be used as an excellent alternat ive to the HPLC stability testing of losartan potassium in COZAAR(R) t ablets. (C) 1998 Elsevier Science B.V. All rights reserved.