REDUCTIVE CYANATION - A KEY STEP FOR A SHORT SYNTHESIS OF (-)-(2S,3S)-3-HYDROXYPROLINE

Authors
DURAND JO LARCHEVEQUE M PETIT Y
Citation
Jo. Durand et al., REDUCTIVE CYANATION - A KEY STEP FOR A SHORT SYNTHESIS OF (-)-(2S,3S)-3-HYDROXYPROLINE, Tetrahedron letters, 39(32), 1998, pp. 5743-5746
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
32
Year of publication
1998
Pages
5743 - 5746
Database
ISI
SICI code
0040-4039(1998)39:32<5743:RC-AKS>2.0.ZU;2-4
Abstract
A short stereoselective synthesis of (-)-(2S,3S)-3-hydroxyproline has been realized from L-malic acid as the source of chirality. The key st ep was the reductive cyanation of the intermediate la, in high stereos electivity and yield. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.