EFFICIENT ROBOTIC SYNTHESIS - MULTICOMPONENT PREPARATION OF A TRICYCLIC TEMPLATE BY SOLID-PHASE TSUGE REACTION

Authors
BICKNELL AJ HIRD NW READSHAW SA
Citation
Aj. Bicknell et al., EFFICIENT ROBOTIC SYNTHESIS - MULTICOMPONENT PREPARATION OF A TRICYCLIC TEMPLATE BY SOLID-PHASE TSUGE REACTION, Tetrahedron letters, 39(32), 1998, pp. 5869-5872
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
32
Year of publication
1998
Pages
5869 - 5872
Database
ISI
SICI code
0040-4039(1998)39:32<5869:ERS-MP>2.0.ZU;2-7
Abstract
Sequential cycloaddition of maleimides and nitrile oxides to resin-bou nd pyridinium methylides gives, after cleavage, maleimide-fused indoli zinium carboxylates. The reaction occurs under mild conditions and has been automated on the ACT 496 synthesiser, providing an efficient mul ti-component robotic synthesis of a diversely substituted tricyclic te mplate from a monocyclic precursor. (C) 1998 Elsevier Science Ltd. All rights reserved.