ANTIOXIDANT SYSTEMIC EFFECT OF SHORT-TERM CEREBROLYSIN(R) ADMINISTRATION

Levels of catalase (CAT) and superoxide dismutase (SOD) activity were determinate in serum of intact rats (INT) and those with septohippocam pal pathway lesion (SHPL), which recieved Cerebrolysin(R) (CRB) or sal ine solution (SAL) for a week. We found that Cerebrolysin(R) induces a decrease on the CAT and SOD levels. Decrease of CAT levels (19.1) in the group of SHPL-CRB was higher than the values obtained (57.3) in SH PL-SAL group. The lowest CAT levels were detected in the INT-CER group (16.7). The SOD levels obtained in SHPL-CER group (9.84) were also sm aller than those obtained in the SHPL-SAL group (14.9) which showed th e highest levels of SOD, while the INT animals showed the lowest level s (7.6). In addition, the SHPL animals mortality was of 18% for the CE R group against 43% for SAL group. We suggest the Cerebrolysin(R) effe ct on CAT and SOD activity is related with a beneficial antioxidative role which may have potential application on brain injury.