We describe a 24-year-old woman with many of the classical features of
the Proteus syndrome. In childhood she had undergone bilateral forefo
ot amputations because of massive bilateral cerebriform hypertrophy of
the feet. Other features include abnormally large fingers on one hand
, a lymphangioma circumscriptum, an epidermal naevus, prominent venous
varicosities and scattered lipomas. The disorder occurs sporadically
and is thought to be secondary to a postzygotic mutation that survives
by mosaicism.