DIAGNOSTIC RELEVANCE OF MIB-1 (KI-67) REACTIVITY FOR THE DIAGNOSIS OFENDOCERVICAL GLANDULAR LESIONS

The morphological criteria for the diagnosis of endocervical atypia an d dysplasia are variably defined. Diagnosis is difficult. MIB-1, (Ki-6 7) cell proliferation-associated antigen was detected retrospectively by immunohistochemistry in 230 cervical cone specimens. The percentage of MIB-1 positive cells was 1 to 25% (median 2%) and limited to small hot spots in normal and subnormal glands (140 cases). It was 1 to 30% (median 4%) in endometrioid metaplasia and microglandular hyperplasia (55 cases); 30 to 60 (median 40%) and limited to 1-3 glands in atypia (24 cases); 45 to 60% (median 50%) and diffusely distributed in dyspl asia (5 cases). in situ (3 cases) and invasive (3 cases) adenocarcinom as were characterized by a high % (> 60) of MIB-1 positive cells.