A DYNAMIC ENZYMATIC SWITCH

Authors
KUMMER U BAIER G
Citation
U. Kummer et G. Baier, A DYNAMIC ENZYMATIC SWITCH, The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment, & general theory, 102(29), 1998, pp. 5892-5897
Citations number
32
Categorie Soggetti
Chemistry Physical
Journal title
The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment, & general theory → ACNP
ISSN journal
10895639
Volume
102
Issue
29
Year of publication
1998
Pages
5892 - 5897
Database
ISI
SICI code
1089-5639(1998)102:29<5892:>2.0.ZU;2-U
Abstract
The kinetics of the peroxidase-catalyzed oxidation of iodide was found to be strongly nonlinear under certain conditions. At slightly acidic pH, the reaction behaves like an enzymatic ''iodine clock'', i.e., th e reaction is switched on after a well-defined time depending on the i nitial concentrations of the reactants. This behavior is studied exper imentally and is shown to represent a true dynamic enzymatic switch. N umerical simulations of a mechanistic model strengthen this conclusion .