DIFFERENTIAL-PULSE POLAROGRAPHIC STUDY OF SIMPLE AND MIXED COMPLEXES OF COPPER IONS WITH THE ANTIDEPRESSANT DRUG IMIPRAMINE AND GLUTAMIC-ACID OR HISTIDINE

The formation of binary and ternary complexes of glutamic acid or hist idine and imipramine with Cu(II) has been examined using differential pulse polarographic technique. The reduction of both simple and mixed systems is reversible and controlled by diffusion. The obtained result s reveal the formation of mixed complexes. For the system Cc-Glu-Imip, one mixed complex was formed: Cu(Glu)(Imip)(2) with stability constan t log{beta(12)} = 10.51, while the system Cu-His-Imip forms two comple xes Cu(His)(Imip) and Cu(His)(Imip)(2) with stabilities log{beta(11)} = 6.25 and log{beta(12)} = 8.77, respectively. These experimental valu es were compared with the statistical ones.