COMPARISON OF EFFICACY AND SAFETY OF ORAL FLUCONAZOLE AND TOPICAL CLOTRIMAZOLE IN THE TREATMENT OF TINEA-CORPORIS, TINEA-CRURIS, TINEA-PEDIS, AND CUTANEOUS CANDIDIASIS
B. Crevits et al., COMPARISON OF EFFICACY AND SAFETY OF ORAL FLUCONAZOLE AND TOPICAL CLOTRIMAZOLE IN THE TREATMENT OF TINEA-CORPORIS, TINEA-CRURIS, TINEA-PEDIS, AND CUTANEOUS CANDIDIASIS, Current therapeutic research, 59(7), 1998, pp. 503-510
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy","Medicine, Research & Experimental
The safety and efficacy of oral fluconazole 150 mg once weekly were co
mpared with those of topical clotrimazole 1% cream twice daily in the
treatment of tinea corporis, tinea cruris, tinea pedis, and cutaneons
candidiasis. A total of 391 patients were enrolled in 19 centers in 12
countries. Treatment lasted 2 to 4 weeks for patients with tinea corp
oris, tinea cruris, or cutaneous candidiasis, and up to 6 weeks for pa
tients with tinea pedis. Fluconazole and clotrimazole were relatively
comparable in clinical outcome in nearly all infections at the end of
therapy and at the long-term follow-up visit (28 to 35 days after the
last dose). No statistically significant between-group difference was
observed in the rate of eradication of the original pathogen for tinea
corporis, tinea cruris, or cutaneous candidiasis. For tinea pedis, ho
wever, fluconazole was less effective than clotrimazole. Safety profil
es were comparable in the two treatment groups-both agents were well t
olerated with minimal adverse events. Results of this trial demonstrat
ed that oral fluconazole 150 mg once weekly and topical clotrimazole 1
% cream twice daily are comparable in safety and efficacy for the trea
tment of certain superficial fungal infections. In addition, fluconazo
le provides convenient once-weekly dosing, which may lead to greater p
atient compliance.