BONE-MARROW CHANGES IN INFECTIOUS-DISEASES AND LYMPHOHEMATOPOIETIC NEOPLASIAS IN DOGS AND CATS - A RETROSPECTIVE STUDY

Bone-marrow changes in infectious diseases due to feline infectious pe ritonitis virus (FIPV): feline immunodeficiency virus (FIV): parvoviru s (PV; canine and feline) and canine distemper virus (CDV), and in the lymphohaemopoietic neoplasias (LHNs) usually associated with feline l eukaemia virus infection were studied in samples obtained from 204 cat s and 82 dogs at necropsy. The study demonstrated (1) no changes, (2) non-specific reactive changes, and (3) disease-specific changes (simil ar to those occurring in extramedullary sites) in: 51.2; 48.8 and 9.7% of 41 cases of FIPV infection, respectively; 0, 100 and 0% of nine ca ses of FIV infection, respectively; 1 3, 0 and 92% of 75 cases of cani ne PV infection? respectively; 5.3, 3.9 and 84% of 76 cases of feline PV infection, respectively; 71.4, 28.6 and 0% of seven cases of CDV in fection; respectively; and 35.9, 52.6 and 11.5% of 78 cases of LHN, re spectively. The distribution of the disease-specific bone-marrow chang es was either diffuse or focal; diffuse changes were frequently found in cases of feline and canine PV infection, and focal changes were fou nd inconsistently in FIPV infections and feline LHN. To the extent tha t the bone marrow showed any changes in FIV and CDV infections, they w ere mostly reactive and not pathognomonic. (C) 1998 W.B. Saunders Comp any Limited.