QUANTITATIVE ASSAY FDR EPINEPHRINE IN DENTAL ANESTHETIC SOLUTIONS BY CAPILLARY-ELECTROPHORESIS

A simple and robust method for the separation and quantification of ep inephrine in dental anesthetic solutions was developed. The method all ows the direct injection of high salt solutions without Sample pre-tre atment. Large sample plugs (5.7% of the total capillary length) are us ed for epinephrine determination by selective analyte focusing in capi llary electrophoresis, The concentration detection limit for epinephri ne is about 5.0 x 10(-7) M (90 ng ml(-1)) with a commercial UV detecto r. The separation protocol was validated in terms of its precision, li nearity, accuracy and specificity.