Structural alterations of mouse skin collagen fibrils brought about by
treatment with lithium chloride at various doses, as studied by elect
ron microscopy, are discussed. The effect of the duration of treatment
on such fibrils is also investigated. An analysis of positive stainin
g patterns from fibrils from mice treated with lithium is included. In
addition, this review describes how computer analyses of electron-opt
ical images from collagen fibrils can lead to information about the ch
anges produced by lithium on the molecular architecture of the fibril.
(C) 1998 Elsevier Science Ltd. All rights reserved.